Graphene FET-based Biomarker Detection

Selective and rapid detection of biomarkers is of critical importance in modern day health care for early stage diagnosis to prevent fatal diseases and infections. We are currently developing a reliable, selective, and label-free protein biomarker sensor by utilizing a graphene field-effect transistor (GFET) device functionalized with single-stranded DNA-based aptamers. When the target molecules bind to the surface-immobilized aptamers, the resulting shift in the charge neutrality point of the GFET device, also known as the Dirac voltage, varied systematically with the concentration of target protein. The experimental results show that the GFET-based biosensor is capable of detecting lysozyme molecules in the concentration range from 10 nM to 1 µM.


© 2019 by Edward Song at University of New Hampshire, Durham NH USA